Collaboration through chromatin: motors of transcription and chromatin structure
نویسندگان
چکیده
منابع مشابه
Regulation of transcription by bent DNA through chromatin structure
A class of bent DNA is present in the genomic DNA of higher eukaryotes as a repeating unit (Kiyama, R., Gene Ther. Mol. Biol. 1, 641-647, 1998). This bent DNA appears once every 680 bp on average, and often shows periodicity, suggesting biological significance. By having a higher affinity for histone core particles, it has a role in designating a key nucleosome, which initiates nucleosome align...
متن کاملEtiology and Evaluation of Sperm Chromatin Anomalies
Evidence suggests that human sperm chromatin anomalies adversely affect reproductive outcomes and infertile men possess substantially amount of sperm with chromatin anomalies than fertile men. Routine semen analysis evaluates parameters such as sperm motility and morphology, but does not examine the nuclear DNA integrity of spermatozoa. It has been suggested that altered nuclear chromatin struc...
متن کاملStudying Chromatin Dynamics In Vitro: Chromatin Assembly, Remodeling, and Transcription
As outlined in the preceding chapters, an outstanding problem in the field of eukaryotic gene regulation is understanding the biochemical mechanism by which gene-specific activators regulate transcription. In Chapters 11 and 12, we discussed biochemical strategies to dissect how these transcriptional regulators interact with their cognate DNA sequences and enhance transcription from DNA templat...
متن کاملDNA microarrays, chromatin, transcription
The DNA microarray-based technique has been developed to semi-quantitatively measure the in vivo global chromatin condensation state at the resolution of a gene. Chromatin was fractionated due to the differential solubility of histone H1-containing and histone H1-free nucleosomes. A set of genes non-randomly distributed between histone H1-free (uncondensed or open) and histone H1-containing (co...
متن کاملChromatin Remodeling: RSC Motors along the DNA
Single-molecule experiments show that the chromatin-remodeling complex RSC, a member of the SNF2 ATPase family, induces formation of a negatively supercoiled DNA loop by active translocation.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Molecular Biology
سال: 2021
ISSN: 0022-2836
DOI: 10.1016/j.jmb.2021.166876